Thymosin-Beta 4 (TMSB4X) Active Protein | TMSB4X active protein

Recombinant Human Thymosin-Beta 4 (TMSB4X)

Cat. Num. AAA4159813

• Gene Names: TMSB4X; FX; TB4X; PTMB4; TMSB4
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Thymosin-Beta 4 (TMSB4X); Recombinant Human Thymosin-Beta 4 (TMSB4X); T beta-4; Hematopoietic system regulatory peptide; Seraspenide; TMSB4X; TB4X; TMSB4; TMSB4X active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS
• Sequence Length: 44

• Bioactivity: The ED(50) was determined by the dose-dependent proliferation of immortalized mouse brain endothelial cells and was found to be <0.5ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: Reconstitute at 100 ug/mL in sterile PBS
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for TMSB4X active protein

The primary function of the T beta-4 member of the Thymosin-beta family is to maintain the organization of the cell's cytoskeletal structure. Produced by myoblasts and fibroblasts, TMSB4X acts as a modulator for the production and digestion of actin and to inhibit filamentous actin polymerization. TMSB4X has also been found to induce phenotypic changes in T cell lines during early host defence mechanisms and inhibit the progression of hematopoietic pluripotent stem cells into the s-phase.

NCBI and Uniprot Product Information

• NCBI GI #: 11056061
• NCBI GeneID: 7114
• NCBI Accession #: NP_066932.1
• NCBI GenBank Nucleotide #: NP_066932.1
• UniProt Accession #: P62328
• Molecular Weight: 5.2 kDa
• NCBI Official Full Name: thymosin beta-4
• NCBI Official Synonym Full Names: thymosin beta 4 X-linked
• NCBI Official Symbol: TMSB4X
• NCBI Official Synonym Symbols: FX; TB4X; PTMB4; TMSB4
• NCBI Protein Information: thymosin beta-4
• UniProt Protein Name: Thymosin beta-4
• Protein Family: Thymosin
• UniProt Gene Name: TMSB4X
• UniProt Synonym Gene Names: TB4X; THYB4; TMSB4; T beta-4
• UniProt Entry Name: TYB4_HUMAN

NCBI Description

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

Uniprot Description

TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: Xq21.3-q22

Cellular Component: cytoskeleton; extracellular region

Molecular Function: actin monomer binding; protein binding

Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation