S100a9 protein Active Protein | S100a9 active protein

Recombinant Mouse S100a9 protein (His Tag)

Cat. Num. AAA2569377

• Gene Names: S100a9; p14; Cagb; GAGB; L1Ag; BEE22; MRP14; 60B8Ag; AW546964
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: S100a9 protein; Recombinant Mouse S100a9 protein (His Tag); Leukocyte L1 complex heavy chain; 60B8AG; CAGB; Calgranulin B; Calgranulin-B; Calprotectin L1H subunit; CFAG; CGLB; Cystic fibrosis antigen B; L1AG; LIAG; MAC387; MIF; Migration inhibitory factor related protein 14; Migration inhibitory factor-related protein 14; MRP 14; MRP-14; MRP14; Myeloid-related protein 14; NIF; OTTHUMP00000015331; p14; Protein S100-A9; S100 A9; S100 calcium binding protein A9; S100 calcium binding protein A9 calgranulin B; S100 calcium-binding protein A9; S100A9; S10A9; S100a9 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: 2A-113K

• Species: Mouse
• Tag: N/C-His
• Protein Construction: A DNA sequence encoding the Mouse S100a9(P31725)(2A-113K) was expressed with a polyhistidine tag at the N-terminus.
• Activity: Immunogen (E-AB-40341)
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for S100a9 active protein

S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.

NCBI and Uniprot Product Information

• NCBI GI #: 529367291
• NCBI GeneID: 20202
• NCBI Accession #: NP_001268781.1
• NCBI GenBank Nucleotide #: NM_001281852.1
• UniProt Accession #: P31725
• Molecular Weight: 13,049 Da
• NCBI Official Full Name: protein S100-A9
• NCBI Official Synonym Full Names: S100 calcium binding protein A9 (calgranulin B)
• NCBI Official Symbol: S100a9
• NCBI Official Synonym Symbols: p14; Cagb; GAGB; L1Ag; BEE22; MRP14; 60B8Ag; AW546964
• NCBI Protein Information: protein S100-A9; S100 calcium-binding protein A9; leukocyte L1 complex heavy chain; migration inhibitory factor-related protein 14
• UniProt Protein Name: Protein S100-A9
• Protein Family: Protein
• UniProt Gene Name: S100a9
• UniProt Synonym Gene Names: Cagb; Mrp14; MRP-14; p14
• UniProt Entry Name: S10A9_MOUSE

Uniprot Description

S100A9: a calcium-binding regulatory protein of the S-100 family expressed by macrophages in acutely inflammated tissues and in chronic inflammations. May be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells. Interacts with CEACAM3 in a calcium-dependent manner.

Protein type: Calcium-binding

Cellular Component: extracellular space; cytoskeleton; membrane; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: antioxidant activity; arachidonic acid binding; RAGE receptor binding; zinc ion binding; microtubule binding; metal ion binding; calcium ion binding

Biological Process: caspase activation; neutrophil chemotaxis; immune system process; apoptosis; leukocyte chemotaxis; positive regulation of peptide secretion; chemotaxis; leukocyte migration during inflammatory response; regulation of inflammatory response; actin cytoskeleton reorganization; innate immune response; autophagy; regulation of integrin biosynthetic process; inflammatory response; positive regulation of inflammatory response