Protein disulfide-isomerase protein (P4HB) Active Protein | P4HB active protein
Recombinant Human Protein disulfide-isomerase protein (P4HB) (Active)
Thiol Protein Reductase Activity is 0.001 Delta650nm/ min-2, determined by measuring the turbidity increase at 650 nm due to insulin reduction. The activity is expressed as the ratio of the slope of a linear part of the turbidity curve to the lag time.
Isomerase activity:
Isomerase Activity is 0.5 µmol active RNase A min-1 µmol PDI-1, according to the re-activation of reduced and denatured RNase A.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Uniprot Description
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
Research Articles on P4HB
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Product Notes
The P4HB p4hb (Catalog #AAA969127) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-508. Partial. The amino acid sequence is listed below: MRGSGSHHHH HH+APEEEDH VLVLRKSNFA EALAAHKYLL VEFYAPWCGH CKALAPEYAK AAGKLKAEGS EIRLAKVDAT EESDLAQQYG VRGYPTIKFF RNGDTASPKE YTAGREADDI VNWLKKRTGP AATTLPDGAA AESLVESSEV AVIGFFKDVE SDSAKQFLQA AEAIDDIPFG ITSNSDVFSK YQLDKDGVVL FKKFDEGRNN FEGEVTKENL LDFIKHNQLP LVIEFTEQTA PKIFGGEIKT HILLFLPKSV SDYDGKLSNF KTAAESFKGK ILFIFIDSDH TDNQRILEFF GLKKEECPAV RLITLEEEMT KYKPESEELT AERITEFCHR FLEGKIKPHL MSQELPEDWD KQPVKVLVGK NFEDVAFDEK KNVFVEFYAP WCGHCKQLAP IWDKLGETYK DHENIVIAKM DSTANEVEAV KVHSFPTLKF FPASADRTVI DYNGERTLDG FKKFLESGGQ DGAGDDDDLE DLEEAEEPDM EEDDDQKAVK DEL . It is sometimes possible for the material contained within the vial of "Protein disulfide-isomerase protein (P4HB), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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