Procalcitonin Active Protein | CALCA active protein

Procalcitonin, human recombinant

Cat. Num. AAA844774

• Gene Names: CALCA; CT; KC; CGRP; CALC1; CGRP1; CGRP-I
• Applications: SDS-Page
• Purity: >=97%
• Synonyms: Procalcitonin; human recombinant; calcitonin; CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; MGC126648; CALCA active protein

• Host: E Coli
• Purity/Purification: >=97%
• Form/Format: Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.; Appearance: Lyophilized protein
• Sequence Length: 141

• Applicable Applications for CALCA active protein: SDS-PAGE; HPLC
• Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.
• Biological Activity: Human Procalcitonin was tested using Biomerieux reagents on the Min-Vidas. The assay was run at 80 ng/ml with a recovery of 82 percent.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for CALCA active protein

Background: Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed Procalcitonin rise significantly after bacterial infection, trauma or shock. Recombinant Human Procalcitonin produced in E.coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.

Product Categories/Family for CALCA active protein

Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 76880484
• NCBI GeneID: 796
• NCBI Accession #: NP_001029124.1
• NCBI GenBank Nucleotide #: NM_001033952.2
• UniProt Accession #: P01258; Q13935; Q13937; Q52LX7; B7ZL39; P06881
• Molecular Weight: 13. 2 kDa
• NCBI Official Full Name: calcitonin isoform CT preproprotein
• NCBI Official Synonym Full Names: calcitonin-related polypeptide alpha
• NCBI Official Symbol: CALCA
• NCBI Official Synonym Symbols: CT; KC; CGRP; CALC1; CGRP1; CGRP-I
• NCBI Protein Information: calcitonin; calcitonin gene-related peptide 1
• UniProt Protein Name: Calcitonin
• Protein Family: Calcitonin
• UniProt Gene Name: CALCA
• UniProt Synonym Gene Names: CALC1; CCP
• UniProt Entry Name: CALC_HUMAN

NCBI Description

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Uniprot Description

CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular space; cell soma; cytoplasm; extracellular region; terminal button; nucleus

Molecular Function: identical protein binding; protein binding; calcitonin receptor binding; hormone activity; protein complex binding; receptor binding

Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; protein amino acid phosphorylation; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; vasculature development; cell-cell signaling; neuropeptide signaling pathway; negative regulation of smooth muscle contraction; regulation of blood pressure; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; positive regulation of macrophage differentiation; inflammatory response; negative regulation of bone resorption; detection of temperature stimulus involved in sensory perception of pain; negative regulation of neurological process; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; regulation of inflammatory response; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation