MIP-3 beta (CCL19) Active Protein | MIP-3 beta active protein

Recombinant Human MIP-3 beta (CCL19)

Gene Names

CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19

Purity

>95% as determined by SDS-PAGE

Synonyms

MIP-3 beta (CCL19); Recombinant Human MIP-3 beta (CCL19); MIP-3-beta; C-C motif chemokine 19; MIP3; Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Small-inducible cytokine A19; Exodus-3; Recombinant Human Macrophage Inflammatory Protein-3 Beta (CCL19); MIP-3 beta active protein

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Cat. Num. AAA4159807 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli

Purity/Purification

>95% as determined by SDS-PAGE

Form/Format

Lyophilized from a 0.2 um filtered solution in Acetonitrile and TFA with BSA as a carrier protein

Sequence Length

Bioactivity

Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED(50) for this effect is typically 0.1-0.3 ug/mL.

Endotoxin Level

<1.0 EU/ug of recombinant protein as determined by the LAL method.

Reconstitution

Reconstitute at 25 ug/mL in sterile PBS containing at least 0.1% human or bovine serum albumin

Preparation and Storage

The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Related Product Information for MIP-3 beta active protein

CCL19 is a chemokine that belongs to the CC family of growth factors and signals through the CCR7 receptor. CCl19 has been shown to be expressed in the thymus, lymph nodes and in activated bone marrow stromal cells. When anti-inflammatory signals are released, expression of CCL19 gets down-regulated-specifically by IL-10.

NCBI and Uniprot Product Information

NCBI GI #

1791003

NCBI GeneID

6363

UniProt Accession #

Q99731

Molecular Weight

9.1 kDa

NCBI Official Full Name

macrophage inflammatory protein 3 beta

NCBI Official Synonym Full Names

C-C motif chemokine ligand 19

NCBI Official Symbol

CCL19

NCBI Official Synonym Symbols

ELC; CKb11; MIP3B; MIP-3b; SCYA19

NCBI Protein Information

C-C motif chemokine 19

UniProt Protein Name

C-C motif chemokine 19

UniProt Gene Name

CCL19

UniProt Synonym Gene Names

ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta

UniProt Entry Name

CCL19_HUMAN

NCBI Description

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; cell communication; positive regulation of T cell proliferation; establishment of T cell polarity; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation

Research Articles on MIP-3 beta

1. In the present study, high levels of CC motif ligand 19 (CCL19), signaling pathways such as Tolllike receptor 4 (TLR4)/nuclear factorkappaB (NFkappaB), and proinflammatory factors including interleukin6 (IL6) and tumor necrosis factora (TNFa) were detected in Nonalcoholic fatty liver disease patients

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Product Notes

The MIP-3 beta ccl19 (Catalog #AAA4159807) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MIP-3 beta (CCL19), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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