Macrophage Inflammatory Protein-1 alpha (rHuMIP-1 alpha) Active Protein | rHuMIP-1 alpha active protein
Human Macrophage Inflammatory Protein-1 alpha (rHuMIP-1 alpha)
Gene Names
CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
Purity
Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Synonyms
Macrophage Inflammatory Protein-1 alpha (rHuMIP-1 alpha); Human Macrophage Inflammatory Protein-1 alpha (rHuMIP-1 alpha); rHuMIP-1 alpha active protein
Host
E Coli
Purity/Purification
Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Form/Format
Sterile filtered, lyophilized.
Sequence Length
70
Biological Activity
Fully biologically active compared to references standards. Activity determined by the ability to chemoattract human monocytes at a concentration of 1-10ng/ml.
Endotoxin
<0.1 ng/ug
Stabilizers
None
Preservatives
None
Protein Content
Determined spectrophotometrically at 280nm (extinction coefficient 0.9) and by RP-HPLC analysis against a calibrated standard.
Dimers/Aggregates
<1% by SDS-PAGE
Reconstitution
Reconstitute the lyophilized product in sterile water not less than 100 ug/ml.
Preparation and Storage
Lyophilized product is stable at room temperature for 3 weeks.
Store lyophilized product desiccated at-20 degree C.
Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at-20 degree C.
For long-term storage add either HSA or BSA to 0.1%.
Avoid repeated freeze-thaw cycles.
Store lyophilized product desiccated at-20 degree C.
Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at-20 degree C.
For long-term storage add either HSA or BSA to 0.1%.
Avoid repeated freeze-thaw cycles.
Related Product Information for rHuMIP-1 alpha active protein
Recombinant Human MIP-1 alpha; produced in E Coli is a single, non-glycosated, polypeptide chain containing 70 amino acids with a molecular mass of 7,820 daltons. This product has full biological activity.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
10,085 Da
NCBI Official Full Name
macrophage inflammatory protein 1 alpha, partial
NCBI Official Synonym Full Names
C-C motif chemokine ligand 3
NCBI Official Symbol
CCL3
NCBI Official Synonym Symbols
MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
NCBI Protein Information
C-C motif chemokine 3
UniProt Protein Name
C-C motif chemokine 3
UniProt Gene Name
CCL3
UniProt Synonym Gene Names
G0S19-1; MIP1A; SCYA3; MIP-1-alpha
NCBI Description
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Uniprot Description
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Research Articles on rHuMIP-1 alpha
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Product Notes
The rHuMIP-1 alpha ccl3 (Catalog #AAA191487) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Macrophage Inflammatory Protein-1 alpha (rHuMIP-1 alpha), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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