IL22 active protein

Recombinant Human IL22

Cat. Num. AAA4159716

• Gene Names: IL22; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• Purity: >95% as determined by SDS-PAGE
• Synonyms: IL22; Recombinant Human IL22; IL-22; IL-TIF; Cytokine Zcyto18; IL-10-related T cell-derived-inducible factor; ILTIF; ZCYTO18; Recombinant Human Interleukin-22 (IL22); IL22 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from 0.2 um filtered concentrated (1.0 mg/mL) solution in 500 mM NaCl, 20 mM Tris, pH 8.0.
• Sequence Length: 179

• Bioactivity: Activity was determined by the ability to inhibit growth of human A549 cancer cells at concentrations ranging between 50-100 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for IL22 active protein

Originally identified as a gene induced by IL-9 in mouse T cells and mast cells, IL-22 is a member of the IL-10 family of cytokines. IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the pancreas and liver. The IL-22 receptor complex consists of two receptor subunits, IL-22R and IL-10R-beta that belong to the class II cytokine receptor family. Recombinant human IL-22 is a non-disulfide-linked homodimeric protein.

NCBI and Uniprot Product Information

• NCBI GI #: 10092625
• NCBI GeneID: 50616
• NCBI Accession #: NP_065386.1
• NCBI GenBank Nucleotide #: NP_065386.1
• UniProt Accession #: Q9GZX6
• Molecular Weight: 17.0 kDa
• NCBI Official Full Name: interleukin-22
• NCBI Official Synonym Full Names: interleukin 22
• NCBI Official Symbol: IL22
• NCBI Official Synonym Symbols: TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• NCBI Protein Information: interleukin-22
• UniProt Protein Name: Interleukin-22
• Protein Family: Interleukin
• UniProt Gene Name: IL22
• UniProt Synonym Gene Names: ILTIF; ZCYTO18; IL-22; IL-TIF
• UniProt Entry Name: IL22_HUMAN

NCBI Description

This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

Uniprot Description

IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-22 receptor binding; cytokine activity

Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response