IL-17A active protein
IL-17A (mouse), (recombinant)
Gene Names
Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A
Purity
>=95% (SDS-PAGE)
Synonyms
IL-17A; IL-17A (mouse); (recombinant); IL-17A active protein
Host
E Coli
Purity/Purification
>=95% (SDS-PAGE)
Form/Format
Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Amino Acids
Contains 134/268 amino acids
Endotoxin
<=1EU/ug protein (LAL test)
Biological Activity
Production of IL-6 by mouse 3T3 cells; ED50 <=5 ng/mL (>=2.0x105 units/mg)
Reconstitution
Reconstitute in sterile water at 0.1mg/mL
Preparation and Storage
For long term storage, store at -80 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80 degree C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80 degree C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution
Related Product Information for IL-17A active protein
Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a pro-inflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. Cytokines and chemokines then mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites. Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.
Product Categories/Family for IL-17A active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,490 Da
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
Il17a
NCBI Official Synonym Symbols
Il17; Ctla8; IL-17; Ctla-8; IL-17A
NCBI Protein Information
interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8
UniProt Protein Name
Interleukin-17A
UniProt Gene Name
Il17a
UniProt Synonym Gene Names
Ctla8; Il17; IL-17; IL-17A; CTLA-8
UniProt Entry Name
IL17_MOUSE
Uniprot Description
IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane
Molecular Function: cytokine activity
Biological Process: positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Research Articles on IL-17A
Similar Products
Product Notes
The IL-17A il17a (Catalog #AAA567244) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-17A, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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