Exendin 4 Active Protein
Exendin 4, Recombinant
Purity
Highly Purified>95% by RP-HPLC and SDS-PAGE. Chromatographically purified.
Synonyms
Exendin 4; Recombinant; Exendin 4 active protein
Host
E Coli
Purity/Purification
Highly Purified
>95% by RP-HPLC and SDS-PAGE. Chromatographically purified.
>95% by RP-HPLC and SDS-PAGE. Chromatographically purified.
Form/Format
Supplied as a lyophilized powder from 20mM PBS and 4% mannitol. Reconstitute in sterile ddH2O to 0.1mg/ml. Add 0.1% HSA or BSA for long term storage. This solution can then be diluted into other aqueous solutions.
Sequence
The sequence was determined and was found to be: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser.
Biological Activity
1. Regulates Glucose levels rapidly.
2. Reduces Insulin resistance.
3. Reduces Glucagon.
4. Reduces HbA1c.
5. Stimulates beta cell growth which stimulates insulin production.
2. Reduces Insulin resistance.
3. Reduces Glucagon.
4. Reduces HbA1c.
5. Stimulates beta cell growth which stimulates insulin production.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O to 0.1mg/ml. Add a carrier protein (0.1% HSA or BSA) for long term storage. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Exendin 4 active protein
Recombinant Exendin-4 is a glucagon like peptide-1 receptor agonist. The native hormone is produced in the gut of Gila monster Heloderma suspectrum (a type of reptile found in the desert) that stimulates insulin production without causing threateningly low blood sugar, which can occur after using insulin and some anti-diabetes products. Recently, researchers used extracted saliva from gila monsters to create an unprecedented breakthrough in Diabetes Type 2 treatment. Exedin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion and slows gastric emptying in vivo. It also promotes B-cell proliferation and neogenesis in vitro and in animal models. Exedin-4 stimulates an increase in acinar cAMP, without stimulating the release of amylase.
Recombinant Exendin-4 is a novel 39-amino acids peptide having a molecular mass of 4186.7 dalton, which shares 53%, sequence homology with GLP-17-36 amide and interacts with the same membrane receptor.
Recombinant Exendin-4 is a novel 39-amino acids peptide having a molecular mass of 4186.7 dalton, which shares 53%, sequence homology with GLP-17-36 amide and interacts with the same membrane receptor.
Product Categories/Family for Exendin 4 active protein
NCBI and Uniprot Product Information
Uniprot Description
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
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Product Notes
The Exendin 4 (Catalog #AAA636040) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The sequence was determined and was found to be: His-Gly-Gl u-Gly-Thr- Phe-Thr-Se r-Asp-Leu- Ser-Lys-Gl n-Met-Glu- Glu-Glu-Al a-Val-Arg- Leu-Phe-Il e-Glu-Trp- Leu-Lys-As n-Gly-Gly- Pro-Ser-Se r-Gly-Ala- Pro-Pro-Pr o-Ser. It is sometimes possible for the material contained within the vial of "Exendin 4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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