CXCL16 active protein
Recombinant Human CXCL16
Gene Names
CXCL16; SRPSOX; CXCLG16; SR-PSOX
Purity
Greater than 97.0% as determined by SDS-PAGE.
Synonyms
CXCL16; Recombinant Human CXCL16; CXCL16 Human; CXCL16 Human Recombinant; Chemokine (C-X-C Motif) Ligand 16; Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; Transmembrane Chemokine CXCL16; Small-Inducible Cytokine B16; CXC Chemokine Ligand 16; SR-PSOX; SRPSOX; C-X-C Motif Chemokine 16; CXCLG16; SCYB16; CXCL16 active protein
Host
E Coli
Purity/Purification
Greater than 97.0% as determined by SDS-PAGE.
Form/Format
CXCL16 protein was lyophilized from a 0.2 um filtered solution in PBS.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP
Sequence Length
273
Biological Activity
The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml.
Solubility
It is recommended to reconstitute the lyophilized CXCL16 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL16 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for CXCL16 active protein
Introduction: CXC chemokine ligand 16 (CXCL16) is a type I membrane protein, which contains a non-ELR motif-containing CXC chemokine domain in its extracellular region. Human and Mouse CXCL16 share a 70% a.a. sequence similarity within their chemokine domains and 49% overall a.a. sequence identity. Functional CXCL16 can be dropped from the cell surface as an approximately 35kDa soluble protein. CXCR6 is the functional receptor for CXCL16. CXCL16 functions as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), proposing that CXCL16 may be involved in pathophysiology such as atherogenesis. In addition, CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 binds to CXCR6/Bonzo.
Description: CXCL16 Human Recombinant (30-118 a.a.) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 89 amino acids and having a molecular mass of 10kDa.The CXCL16 is purified by proprietary chromatographic techniques.
Description: CXCL16 Human Recombinant (30-118 a.a.) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 89 amino acids and having a molecular mass of 10kDa.The CXCL16 is purified by proprietary chromatographic techniques.
Product Categories/Family for CXCL16 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,579 Da
NCBI Official Full Name
C-X-C motif chemokine 16
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 16
NCBI Official Symbol
CXCL16
NCBI Official Synonym Symbols
SRPSOX; CXCLG16; SR-PSOX
NCBI Protein Information
C-X-C motif chemokine 16
UniProt Protein Name
C-X-C motif chemokine 16
Protein Family
UniProt Gene Name
CXCL16
UniProt Synonym Gene Names
SCYB16; SRPSOX; SR-PSOX
UniProt Entry Name
CXL16_HUMAN
Uniprot Description
CXCL16: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: extracellular region; extracellular space; membrane
Molecular Function: chemokine activity; low-density lipoprotein receptor activity; scavenger receptor activity
Biological Process: positive regulation of cell growth; positive regulation of cell migration; response to cytokine stimulus
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Product Notes
The CXCL16 cxcl16 (Catalog #AAA140787) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP. It is sometimes possible for the material contained within the vial of "CXCL16, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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