Mouse dishevelled, dsh homolog 2 (Drosophila) ELISA Kit | DVL2 elisa kit
Mouse Segment polarity protein dishevelled homolog DVL-2, DVL2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: cytoskeleton; membrane; clathrin-coated vesicle; apical part of cell; cytoplasm; plasma membrane; cell cortex; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: protein domain specific binding; identical protein binding; protein binding; protein self-association; frizzled binding
Biological Process: heart morphogenesis; transcription from RNA polymerase II promoter; positive regulation of JNK activity; Wnt receptor signaling pathway; convergent extension involved in neural plate elongation; Wnt receptor signaling pathway, planar cell polarity pathway; heart development; multicellular organismal development; positive regulation of transcription, DNA-dependent; segmentation; Wnt receptor signaling pathway through beta-catenin; segment specification; convergent extension involved in organogenesis; neural tube closure; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation
Research Articles on DVL2
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Product Notes
The Mouse DVL2 dvl2 (Catalog #AAA9325368) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325368 ELISA Kit recognizes Mouse DVL2. It is sometimes possible for the material contained within the vial of "dishevelled, dsh homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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