Mouse dishevelled, dsh homolog 1 (Drosophila) ELISA Kit | DVL1 elisa kit
Mouse Segment polarity protein dishevelled homolog DVL-1, DVL1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Description
DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Cellular Component: microtubule; clathrin-coated vesicle; cell; cytoplasmic membrane-bound vesicle; dendrite; cytosol; microtubule cytoskeleton; growth cone; cell soma; membrane; axon; cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; lateral plasma membrane
Molecular Function: identical protein binding; protein binding; enzyme binding; frizzled binding; Rac GTPase binding; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; axon guidance; prepulse inhibition; axon extension; multicellular organismal development; regulation of neurotransmitter levels; neurotransmitter secretion; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; receptor clustering; cytoplasmic microtubule organization and biogenesis; negative regulation of protein amino acid phosphorylation; collateral sprouting; synapse organization and biogenesis; negative regulation of protein binding; positive regulation of Wnt receptor signaling pathway; neuromuscular junction development; regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; convergent extension involved in neural plate elongation; dendrite morphogenesis; social behavior; convergent extension involved in organogenesis; axonogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation
Research Articles on DVL1
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Product Notes
The Mouse DVL1 dvl1 (Catalog #AAA9325615) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325615 ELISA Kit recognizes Mouse DVL1. It is sometimes possible for the material contained within the vial of "dishevelled, dsh homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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