Dysbindin (Dtnbp1) Recombinant Protein | Dtnbp1 recombinant protein
Recombinant Rat Dysbindin (Dtnbp1)
NCBI and Uniprot Product Information
Uniprot Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
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Product Notes
The Dtnbp1 dtnbp1 (Catalog #AAA1283095) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-352, full length protein. The amino acid sequence is listed below: MLETLRERLL SVQQDFTSGL KTLSDKSKEA KVKSRPRTAP YLPKYSAGLD LLSRYEDTWA ALHRRAKECA DAGELVDSEV VMLSAHWEKK RTSLAELQEQ LQQLPALLQD VESLMASLAH LETSFEEVEN HLLHLEDLCG QCELERHKQA HARHLEDYKK SKRKELEAFK AELDTEHAQK ILEMEHTQQL KLKERQKFFE EAFQQDMEQY LSTGHLQIAE RREPMGSMSS MEVNVDVLEQ MDLMDLSDQE ALDVFLNSGG EDNTVISPGL EMESNPSQNE MNLQIPNPSE SASQPPASPS ACTDLDTADA PLIQADEEEV QVDTALVTLN TDRKSTPGVS DDSDQCDSTQ DI. It is sometimes possible for the material contained within the vial of "Dysbindin (Dtnbp1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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