Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Recombinant Protein | DPM2 recombinant protein
Recombinant Human Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
Uniprot Description
DPM2: Regulates the biosynthesis of dolichol phosphate- mannose. Essential for the ER localization and stable expression of DPM1. Belongs to the DPM2 family.
Protein type: Membrane protein, multi-pass; Transferase; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to endoplasmic reticulum membrane
Molecular Function: dolichyl-phosphate beta-D-mannosyltransferase activity; enzyme regulator activity; protein binding
Biological Process: dolichol metabolic process; GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; protein amino acid N-linked glycosylation via asparagine; protein amino acid O-linked mannosylation; regulation of catalytic activity; regulation of protein stability
Disease: Congenital Disorder Of Glycosylation, Type Iu
Research Articles on DPM2
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Product Notes
The DPM2 dpm2 (Catalog #AAA7013851) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-84aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the DPM2 dpm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ATGTDQVVGL GLVAVSLIIF TYYTAWVILL PFIDSQHVIH KYFLPRAYAV AIPLAAGLLL LLFVGLFISY VMLKTKRVTK KAQ. It is sometimes possible for the material contained within the vial of "Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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