Dopamine receptor 1 (DopR) Recombinant Protein | DopR recombinant protein
Recombinant Drosophila melanogaster Dopamine receptor 1 (DopR)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, DopR expression levels are reduced; sleep may have a role in restoring dopamine homeostasis. Ref.1 Ref.5 Ref.6 Ref.8 Ref.9
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Expressed in the larval and adult CNS in structures that mediate higher-order brain functions such as learning, memory and motor control: in the mushroom body neuropil and four unpaired neurons in each thoracic segment. The adult CNS has intense expression in the central complex, moderate expression in several neurosecretory cells, and weak expression in two unpaired neurons in the mesothoracic neuromere. Also seen in the somata of the optic lobes. Ref.1 Ref.7 Ref.8
Developmental stage: Expressed both maternally and zygotically. Ref.6
Miscellaneous: Potency of neurotransmitter agonists in stimulating cAMP production and the lack of stimulation by other transmitters and metabolites suggests this is a D1-like receptor. Low homology to vertebrate D1 receptors suggests this may be a progenitor of the D1 receptor subfamily.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAF55030.3 differs from that shown. Reason: Erroneous initiation.
Research Articles on DopR
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Product Notes
The DopR dopr (Catalog #AAA1128551) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-142. partial. The amino acid sequence is listed below: MRAIAAIAAG VGSVAATVAT STTSSISSST TIINTSSATT IGGNHTSGST GFSTNSTLLD ADHLPLQLTT AKVDLDIEID IQLLTNGYDG TTLTSFYNES SWTNASEMDT IVGEEPEPLS LVS . It is sometimes possible for the material contained within the vial of "Dopamine receptor 1 (DopR), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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