P2RX7 / P2X7 receptor Blocking Peptide | P2RX7 blocking peptide
P2RX7 / P2X7 receptor Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Uniprot Description
P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: cell soma; cytoplasm; cytosol; external side of plasma membrane; integral to nuclear inner membrane; integral to plasma membrane; intercellular junction; membrane; neuromuscular junction; plasma membrane
Molecular Function: ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding
Biological Process: activation of MAPK activity; bleb formation; blood coagulation; cell morphogenesis; cell surface receptor linked signal transduction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; cytolysis; defense response to Gram-positive bacterium; homeostasis of number of cells within a tissue; inflammatory response; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization and biogenesis; multicellular organismal protein catabolic process; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phagolysosome formation; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of glycolysis; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; positive regulation of T cell mediated cytotoxicity; protein amino acid phosphorylation; protein oligomerization; protein processing; regulation of killing of cells of another organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation
Disease: Leukemia, Chronic Lymphocytic
Research Articles on P2RX7
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Product Notes
The P2RX7 p2rx7 (Catalog #AAA425014) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The P2RX7 / P2X7 receptor Immunizing Peptide reacts with Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: YETNKVTRIQ SMNY-C. It is sometimes possible for the material contained within the vial of "P2RX7 / P2X7 receptor, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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