PTPRM blocking peptide
PTPRM Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
PTPRM: a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported.
Protein type: Receptor protein phosphatase, tyrosine; Phosphatase; Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: cell-cell adherens junction; cytoplasm; integral to plasma membrane; intercellular junction; lamellipodium; perinuclear region of cytoplasm
Molecular Function: cadherin binding; identical protein binding; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: homophilic cell adhesion; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; neurite development; positive regulation of vasodilation; protein amino acid dephosphorylation; response to drug; retinal ganglion cell axon guidance; signal transduction
Research Articles on PTPRM
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Product Notes
The PTPRM ptprm (Catalog #AAA426941) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The PTPRM Immunizing Peptide reacts with Human, Mouse, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KLIRQVDK WQEEYN. It is sometimes possible for the material contained within the vial of "PTPRM, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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