VRK2 blocking peptide
VRK2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Uniprot Description
VRK2: a widely expressed serine/threonine kinase of the CK1 group. A single-pass type IV membrane protein. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis. Modulates the stress response to hypoxia mediated by TAK1. Interacts with JIP1, inhibiting mitogen-activated protein kinase (MAPK) signaling. Interacts with RAN, inhibiting its autophosphorylation. Five human isoforms produced by alternative splicing have been reported. Isoform 1 has a C-terminal hydrophobic region that that associates with the endoplasmic reticulum and mitochondria, colocalizing with calreticulin, calnexin, and mitochondrial markers. Its interaction with JIP1 modulates the stress response to hypoxia and cytokines such as IL1B. Inhibition of signal transmission mediated by the assembly of JIP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates p53 and BAF, inhibiting the latter's ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by HER2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to HER2 and HRAS. Interacts with Epstein-Barr virus BHRF1, protecting cells from apoptosis. Interacts with TAK1, MKK7, MEK1, KSR, RAN and JIP1. Its expression in breast carcinomas inversely correlates with the expression of HER2. Isoform 2 is detected in both the cytoplasm and the nucleus. Phosphorylates p53, reducing its ubiquitination by MDM2 and promoting its acetylation by EP300, thereby increasing the stability and activity of p53.
Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Membrane protein, integral; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; mitochondrial membrane; nucleus; protein complex
Molecular Function: protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process: peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape; regulation of MAPKKK cascade
Research Articles on VRK2
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Product Notes
The VRK2 vrk2 (Catalog #AAA428231) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The VRK2 Immunizing Peptide reacts with Human, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-PNSQKVDS QKAATK. It is sometimes possible for the material contained within the vial of "VRK2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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