Mouse double C2-like domains, beta ELISA Kit | DOC2B elisa kit

Mouse Double C2-like domain-containing protein beta, DOC2B ELISA Kit

Cat. Num. AAA9326226

• Reactivity: Mouse
• Synonyms: double C2-like domains; beta; Mouse Double C2-like domain-containing protein beta; DOC2B ELISA Kit; Mouse Double C2-like domain-containing protein beta (DOC2B) ELISA kit; DOC2BL; beta-like; DOC2B elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Serum, Plasma and Tissue Homogenate
• Assay Type: Sandwich
• Detection Range: 3.12 ng/ml - 100 ng/ml.
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for DOC2B elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of DOC2B (hereafter termed this analyte) in undiluted original Mouse serum, plasma and tissue homogenate samples.

NCBI and Uniprot Product Information

• NCBI GI #: 45433555
• NCBI GeneID: 13447
• NCBI Accession #: NP_031899.2
• NCBI GenBank Nucleotide #: NM_007873.2
• UniProt Accession #: P70169; Q5SS41; Q6NXK3
• Molecular Weight: 45,853 Da
• NCBI Official Full Name: double C2-like domain-containing protein beta
• NCBI Official Synonym Full Names: double C2, beta
• NCBI Official Symbol: Doc2b
• NCBI Protein Information: double C2-like domain-containing protein beta; doc2-beta; double C2 protein beta
• UniProt Protein Name: Double C2-like domain-containing protein beta
• Protein Family: Double C2-like domain-containing protein
• UniProt Gene Name: Doc2b
• UniProt Synonym Gene Names: Doc2-beta
• UniProt Entry Name: DOC2B_MOUSE

NCBI Description

The protein encoded by this gene is a calcium sensor involved in glucose-stimulated insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]

Uniprot Description

DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.

Protein type: Lipid-binding

Cellular Component: SNARE complex; membrane; cell; cytoplasm; plasma membrane

Molecular Function: protein binding; clathrin binding; syntaxin binding; calcium-dependent phospholipid binding; calcium ion binding

Biological Process: vesicle fusion; positive regulation of calcium ion-dependent exocytosis; protein localization; synaptic vesicle exocytosis; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; positive regulation of vesicle fusion; regulation of calcium ion-dependent exocytosis