SDS-Page
(Recombinant Human DNER Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 125-160 kDa.)
DNER recombinant protein
Recombinant Human DNER Protein
Gene Names
DNER; bet; UNQ26
Purity
>97% by SDS-PAGE.
Synonyms
DNER; Recombinant Human DNER Protein; UNQ26; bet; DNER recombinant protein
Host
HEK293 Cells
Purity/Purification
>97% by SDS-PAGE.
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Sequence
RGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRH
Sequence Length
737
Species
Human
Endotoxin
< 0.01 EU/ug of the protein by LAL method.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
Fc, 6xHis tag at the C-terminus
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human DNER Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 125-160 kDa.)
SDS-Page
(Recombinant Human DNER Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 125-160 kDa.)
Related Product Information for DNER recombinant protein
Description: Recombinant Human DNER Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-His637) of human DNER (Accession #NP_620711.3) fused with an Fc, 6xHis tag at the C-terminus.
Background: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family. In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated.Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.
Background: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family. In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated.Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.
Product Categories/Family for DNER recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
delta and Notch-like epidermal growth factor-related receptor
NCBI Official Synonym Full Names
delta/notch like EGF repeat containing
NCBI Official Symbol
DNER
NCBI Official Synonym Symbols
bet; UNQ26
NCBI Protein Information
delta and Notch-like epidermal growth factor-related receptor
UniProt Protein Name
Delta and Notch-like epidermal growth factor-related receptor
UniProt Gene Name
DNER
UniProt Synonym Gene Names
BET
UniProt Entry Name
DNER_HUMAN
Uniprot Description
DNER: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component: cell soma; early endosome; dendrite; plasma membrane; integral to membrane
Molecular Function: clathrin binding; protein binding; transmembrane receptor activity; calcium ion binding; Notch binding
Biological Process: Notch signaling pathway; glial cell differentiation; central nervous system development; synaptogenesis; neuron migration; skeletal muscle fiber development; Notch receptor processing; endocytosis
Research Articles on DNER
Similar Products
Product Notes
The DNER dner (Catalog #AAA9141790) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: RGSSLANPVP AAPLSAPGPC AAQPCRNGGV CTSRPEPDPQ HPAPAGEPGY SCTCPAGISG ANCQLVADPC ASNPCHHGNC SSSSSSSSDG YLCICNEGYE GPNCEQALPS LPATGWTESM APRQLQPVPA TQEPDKILPR SQATVTLPTW QPKTGQKVVE MKWDQVEVIP DIACGNASSN SSAGGRLVSF EVPQNTSVKI RQDATASLIL LWKVTATGFQ QCSLIDGRSV TPLQASGGLV LLEEMLALGN NHFIGFVNDS VTKSIVALRL TLVVKVSTCV PGESHANDLE CSGKGKCTTK PSEATFSCTC EEQYVGTFCE EYDACQRKPC QNNASCIDAN EKQDGSNFTC VCLPGYTGEL CQSKIDYCIL DPCRNGATCI SSLSGFTCQC PEGYFGSACE EKVDPCASSP CQNNGTCYVD GVHFTCNCSP GFTGPTCAQL IDFCALSPCA HGTCRSVGTS YKCLCDPGYH GLYCEEEYNE CLSAPCLNAA TCRDLVNGYE CVCLAEYKGT HCELYKDPCA NVSCLNGATC DSDGLNGTCI CAPGFTGEEC DIDINECDSN PCHHGGSCLD QPNGYNCHCP HGWVGANCEI HLQWKSGHMA ESLTNMPRH. It is sometimes possible for the material contained within the vial of "DNER, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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