Human dynein, axonemal, light chain 1 ELISA Kit | DNAL1 elisa kit
Human Dynein light chain 1, axonemal, DNAL1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Uniprot Description
DNAL1: Defects in DNAL1 are the cause of primary ciliary dyskinesia type 16 (CILD16). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein light chain LC1-type family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q24.3
Disease: Ciliary Dyskinesia, Primary, 16
Research Articles on DNAL1
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Product Notes
The Human DNAL1 dnal1 (Catalog #AAA9323630) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323630 ELISA Kit recognizes Human DNAL1. It is sometimes possible for the material contained within the vial of "dynein, axonemal, light chain 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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