Rat DnaJ (Hsp40) homolog, subfamily C, member 3 ELISA Kit | DNAJC3 elisa kit
Rat DnaJ homolog subfamily C member 3, DNAJC3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mouse homolog inhibits interferon-induced double-stranded RNA-activated protein kinase (PKR) [RGD, Feb 2006]
Uniprot Description
DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Protein type: Inhibitor; Endoplasmic reticulum; Protein kinase, regulatory subunit; Chaperone
Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle
Molecular Function: chaperone binding; misfolded protein binding
Biological Process: negative regulation of protein amino acid phosphorylation; proteolysis involved in cellular protein catabolic process; response to unfolded protein; negative regulation of apoptosis
Research Articles on DNAJC3
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Product Notes
The Rat DNAJC3 dnajc3 (Catalog #AAA9324302) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324302 ELISA Kit recognizes Rat DNAJC3. It is sometimes possible for the material contained within the vial of "DnaJ (Hsp40) homolog, subfamily C, member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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