DnaJ homolog subfamily C member 2 (Dnajc2) Recombinant Protein | Dnajc2 recombinant protein

Recombinant Mouse DnaJ homolog subfamily C member 2 (Dnajc2)

Cat. Num. AAA960929

• Gene Names: Dnajc2; Zrf1; Zrf2; MIDA1; AU020218
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DnaJ homolog subfamily C member 2 (Dnajc2); Recombinant Mouse DnaJ homolog subfamily C member 2 (Dnajc2); Dnajc2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-621, Full length protein
• Sequence: LLLPSAAEGQGTAITHALTSASSVCQVEPVGRWFEAFVKRRNRNASTSFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYTATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFQVFSPVFERNSRWSNKKNVPKLGDMNSSFEDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERKWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEARRKEQEAKEKQRQAELEAVRLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKSWNHFSDNEADRVKMMEEVEKLCDRLELASLQGLNEILASSTREVGKAALEKQIEEVNEQMRREKEEADARMRQASKNAEKSTGGSGSGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVISKAKSLQKLDPHQKDDINKKAFDKFKKEHGVASQADSAAPSERFEGPCIDSTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMRRYKELVEMVKAKKAAQEQVLNASRARK
• Sequence Length: 620

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Dnajc2 recombinant protein

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 6677659
• NCBI GeneID: 22791
• NCBI Accession #: NP_033610.1
• NCBI GenBank Nucleotide #: NM_009584.4
• UniProt Accession #: P54103; Q61866
• Molecular Weight: 71,722 Da
• NCBI Official Full Name: dnaJ homolog subfamily C member 2
• NCBI Official Synonym Full Names: DnaJ heat shock protein family (Hsp40) member C2
• NCBI Official Symbol: Dnajc2
• NCBI Official Synonym Symbols: Zrf1; Zrf2; MIDA1; AU020218
• NCBI Protein Information: dnaJ homolog subfamily C member 2
• UniProt Protein Name: DnaJ homolog subfamily C member 2
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: Dnajc2
• UniProt Synonym Gene Names: Mida1; Zrf1; MIDA1

Uniprot Description

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (). Specifically binds DNA sequence 5'-GTCAAGC-3'.