Mouse DnaJ (Hsp40) homolog, subfamily B, member 6 ELISA Kit | DNAJB6 elisa kit
Mouse DnaJ homolog subfamily B member 6, DNAJB6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DNAJB6: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. Defects in DNAJB6 are the cause of limb-girdle muscular dystrophy type 1E (LGMD1E). An autosomal dominant myopathy characterized by adult onset of proximal muscle weakness, beginning in the hip girdle region and later progressing to the shoulder girdle region. There is evidence that LGMD1E is caused by dysfunction of isoform B (PubMed:22366786). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone
Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus; Z disc
Molecular Function: protein binding; ATPase activator activity; DNA binding; heat shock protein binding; chaperone binding; unfolded protein binding
Biological Process: extracellular matrix organization and biogenesis; protein folding; positive regulation of ATPase activity; intermediate filament organization; negative regulation of caspase activity; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis
Research Articles on DNAJB6
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Product Notes
The Mouse DNAJB6 dnajb6 (Catalog #AAA9336692) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336692 ELISA Kit recognizes Mouse DNAJB6. It is sometimes possible for the material contained within the vial of "DnaJ (Hsp40) homolog, subfamily B, member 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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