Mouse DnaJ (Hsp40) homolog, subfamily A, member 3 ELISA Kit | DNAJA3 elisa kit

Mouse DnaJ homolog subfamily A member 3, mitochondrial, DNAJA3 ELISA Kit

Cat. Num. AAA9333391

• Gene Names: Dnaja3; Tid-1; Tid1l; C81173; 1200003J13Rik; 1810053A11Rik
• Reactivity: Mouse
• Synonyms: DnaJ (Hsp40) homolog; subfamily A; member 3; Mouse DnaJ homolog subfamily A member 3; mitochondrial; DNAJA3 ELISA Kit; mitochondrial (DNAJA3) ELISA kit; FLJ45758; TID1; hTid-1; tumorous imaginal discs homolog; DNAJA3 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 205361114
• NCBI GeneID: 83945
• NCBI Accession #: NP_001128584.1
• NCBI GenBank Nucleotide #: NM_001135112.1
• UniProt Accession #: Q99M87; Q8BSM0; Q99L09; Q99P71; Q99P76; Q9CT11; Q9DBJ7; Q9DC44
• Molecular Weight: 52,443 Da
• NCBI Official Full Name: dnaJ homolog subfamily A member 3, mitochondrial isoform 2
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily A, member 3
• NCBI Official Symbol: Dnaja3
• NCBI Official Synonym Symbols: Tid-1; Tid1l; C81173; 1200003J13Rik; 1810053A11Rik
• NCBI Protein Information: dnaJ homolog subfamily A member 3, mitochondrial; mTid-1; dnaJ protein Tid-1; tumorous imaginal discs protein Tid56 homolog
• UniProt Protein Name: DnaJ homolog subfamily A member 3, mitochondrial
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: Dnaja3
• UniProt Synonym Gene Names: Tid1; mTid-1
• UniProt Entry Name: DNJA3_MOUSE

Uniprot Description

DNAJA3: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; Apoptosis; Cell cycle regulation; Mitochondrial

Cellular Component: extrinsic to plasma membrane; intracellular membrane-bound organelle; mitochondrion; actin filament; IkappaB kinase complex; cytosol; postsynaptic membrane; membrane; mitochondrial matrix; cytoplasm; plasma membrane; synapse; cell junction; nucleus; neuromuscular junction

Molecular Function: NF-kappaB binding; protein binding; chaperone binding; heat shock protein binding; metal ion binding; unfolded protein binding; interferon-gamma receptor binding; GTPase regulator activity; Hsp70 protein binding; receptor tyrosine kinase binding; transcription factor binding; protein kinase binding; ATP binding

Biological Process: protein folding; apoptosis; positive regulation of apoptosis; T cell differentiation in the thymus; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; negative regulation of cell proliferation; regulation of catalytic activity; small GTPase mediated signal transduction; negative regulation of programmed cell death; protein refolding; positive regulation of T cell proliferation; mitochondrial DNA replication; activated T cell apoptosis; neuromuscular junction development; caspase activation; mitochondrion organization and biogenesis; protein stabilization; cell aging; negative regulation of I-kappaB kinase/NF-kappaB cascade; embryonic development; response to heat; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; negative regulation of protein kinase activity; negative regulation of apoptosis