Human DnaJ (Hsp40) homolog, subfamily A, member 3 ELISA Kit | DNAJA3 elisa kit
Human DnaJ homolog subfamily A member 3, mitochondrial, DNAJA3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
DNAJA3: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Chaperone; Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extrinsic to plasma membrane; postsynaptic membrane; intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix; cytoplasm; actin filament; IkappaB kinase complex; cell junction; nucleus; neuromuscular junction; cytosol
Molecular Function: NF-kappaB binding; protein binding; metal ion binding; chaperone binding; unfolded protein binding; interferon-gamma receptor binding; Hsp70 protein binding; receptor tyrosine kinase binding; protein kinase binding; transcription factor binding; ATP binding
Biological Process: caspase activation; mitochondrion organization and biogenesis; protein stabilization; protein folding; positive regulation of apoptosis; T cell differentiation in the thymus; cell aging; negative regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of caspase activity; negative regulation of cell proliferation; regulation of catalytic activity; response to heat; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; small GTPase mediated signal transduction; negative regulation of programmed cell death; negative regulation of protein kinase activity; protein refolding; positive regulation of T cell proliferation; mitochondrial DNA replication; activated T cell apoptosis; neuromuscular junction development; negative regulation of apoptosis
Research Articles on DNAJA3
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Product Notes
The Human DNAJA3 dnaja3 (Catalog #AAA9319685) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319685 ELISA Kit recognizes Human DNAJA3. It is sometimes possible for the material contained within the vial of "DnaJ (Hsp40) homolog, subfamily A, member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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