Human, Mouse Dematin ELISA Kit | DMT; elisa kit
Phospho-Dematin (Ser403) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Uniprot Description
dematin: a probable DNA binding protein, with a Myb-like DNA-binding and ELM2 domain.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: actin cytoskeleton; actin filament; cell projection membrane; cortical cytoskeleton; cytoplasmic vesicle; cytosol; endomembrane system; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; spectrin-associated cytoskeleton
Molecular Function: actin binding; protein binding; protein self-association; receptor binding; spectrin binding
Biological Process: actin cytoskeleton organization; actin filament bundle formation; actin filament capping; actin filament reorganization; cellular response to calcium ion; cellular response to cAMP; cytoskeleton organization; erythrocyte development; negative regulation of cell-substrate adhesion; negative regulation of focal adhesion assembly; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; positive regulation of blood coagulation; positive regulation of fibroblast migration; positive regulation of integrin-mediated signaling pathway; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of wound healing; protein complex assembly; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of filopodium formation; regulation of lamellipodium assembly; transmembrane transport
Research Articles on DMT;
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Product Notes
The Human, Mouse DMT; dmtn (Catalog #AAA9501291) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501291 ELISA Kit recognizes Human, Mouse DMT;. It is sometimes possible for the material contained within the vial of "Dematin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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