Preadipocyte Factor-1/Protein delta Homolog 1/Pref-1/DLK-1 Recombinant Protein | Pref-1/DLK-1 recombinant protein

Recombinant Human Preadipocyte Factor-1/Protein delta Homolog 1/Pref-1/DLK-1 Protein (C-6His)

Cat. Num. AAA2553113

• Gene Names: DLK1; DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Preadipocyte Factor-1/Protein delta Homolog 1/Pref-1/DLK-1; Recombinant Human Preadipocyte Factor-1/Protein delta Homolog 1/Pref-1/DLK-1 Protein (C-6His); Protein Delta Homolog 1; DLK-1; pG2; DLK1; DLK; Pref-1/DLK-1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Positions: Ala24-Pro297
• Sequence Length: 310

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Pref-1/DLK-1 recombinant protein

Protein Delta Homolog 1 (DLK-1) is a transmembrane protein which contains a signal peptide, an extracellular domain with six tandem epidermai growth factor (EGF)-like domains, a single pass transmembrane domain, and a short cytoplasmic tail. It is found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. In addition, it is detected in some forms of neuroendocrine lung tumor tissue. DLK-1 may have a improtant role in neuroendocrine differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 953514558
• NCBI GeneID: 8788
• NCBI Accession #: NP_001304101.1
• NCBI GenBank Nucleotide #: NM_001317172.1
• UniProt Accession #: P80370; P15803; Q96DW5
• Molecular Weight: Molecular Mass: 30.2 kDa; Actual Protein Molecular Mass: 35 kDa
• NCBI Official Full Name: protein delta homolog 1 isoform 2 preproprotein
• NCBI Official Synonym Full Names: delta like non-canonical Notch ligand 1
• NCBI Official Symbol: DLK1
• NCBI Official Synonym Symbols: DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1
• NCBI Protein Information: protein delta homolog 1
• UniProt Protein Name: Protein delta homolog 1
• UniProt Gene Name: DLK1
• UniProt Synonym Gene Names: DLK; DLK-1; FA1

NCBI Description

This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]

Uniprot Description

May have a role in neuroendocrine differentiation.