Human discs, large homolog 2 (Drosophila) ELISA Kit | DLG2 elisa kit
Human Disks large homolog 2, DLG2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Uniprot Description
PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; membrane; basolateral plasma membrane; postsynaptic density; plasma membrane; ionotropic glutamate receptor complex; cell junction
Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; protein binding
Biological Process: establishment and/or maintenance of epithelial cell polarity; synaptic transmission; nervous system development; sensory perception of pain; receptor clustering; nucleotide phosphorylation
Research Articles on DLG2
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Product Notes
The Human DLG2 dlg2 (Catalog #AAA9331838) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331838 ELISA Kit recognizes Human DLG2. It is sometimes possible for the material contained within the vial of "discs, large homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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