Disrupted in schizophrenia 1 homolog (Disc1) Recombinant Protein | Disc1 recombinant protein

Recombinant Rat Disrupted in schizophrenia 1 homolog (Disc1) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Disrupted in schizophrenia 1 homolog (Disc1); Recombinant Rat Disrupted in schizophrenia 1 homolog (Disc1); partial; Disc1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 824

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Disc1 recombinant protein

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI and Uniprot Product Information

• NCBI GI #: 30842815
• NCBI GeneID: 307940
• NCBI Accession #: NP_783186.2
• NCBI GenBank Nucleotide #: NM_175596.2
• UniProt Accession #: Q810H6
• Molecular Weight: 90,102 Da
• NCBI Official Full Name: disrupted in schizophrenia 1 homolog
• NCBI Official Synonym Full Names: disrupted in schizophrenia 1
• NCBI Official Symbol: Disc1
• NCBI Protein Information: disrupted in schizophrenia 1 homolog
• UniProt Protein Name: Disrupted in schizophrenia 1 homolog
• Protein Family: Disrupted in schizophrenia
• UniProt Gene Name: Disc1

NCBI Description

interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia [RGD, Feb 2006]

Uniprot Description

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.