DCN1-Like Protein 1/DCUN1D1 Recombinant Protein | DCUN1D1 recombinant protein

Recombinant Human DCN1-Like Protein 1/DCUN1D1 Protein (N-6His)

Cat. Num. AAA2552584

• Gene Names: DCUN1D1; RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: DCN1-Like Protein 1/DCUN1D1; Recombinant Human DCN1-Like Protein 1/DCUN1D1 Protein (N-6His); DCN1-Like Protein 1; DCUN1 Domain-Containing Protein 1; Defective in Cullin Neddylation Protein 1-Like Protein 1; Squamous Cell Carcinoma-Related Oncogene; DCUN1D1; DCUN1L1; RP42; SCCRO; DCUN1D1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Positions: Met1-Val259
• Sequence Length: 244

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for DCUN1D1 recombinant protein

DCN1-Like Protein 1 is a protein containing 1 DCUN1 domain and 1 UBA-like domain. DCN1-Like Protein 1 contains part of an E3 Ubiquitin Ligase Complex for Neddylation. It is required for Neddylation of Cullin components of E3 Cullin-RING Ubiquitin Ligase complexes. It enhances the rate of Cullins Neddylation. DCN1-Like Protein 1 recruits the NEDD8-charged E2 Enzyme to the Cullin component. DCUN1D1 is involved in the release of inhibitory effects of CAND1 on the Cullin-RING Ligase E3 complex assembly and activity. It acts also as an oncogene facilitating malignant transformation and carcinogenic progression.

NCBI and Uniprot Product Information

• NCBI GI #: 809281410
• NCBI GeneID: 54165
• NCBI Accession #: NP_001295030.1
• NCBI GenBank Nucleotide #: NM_001308101.1
• UniProt Accession #: Q96GG9; Q7L3G9; Q8TEX7; Q9H6M1; Q9HCT3; B2RB37
• Molecular Weight: Molecular Mass: 32.3 kDa; Actual Protein Molecular Mass: 32 kDa
• NCBI Official Full Name: DCN1-like protein 1 isoform 2
• NCBI Official Synonym Full Names: defective in cullin neddylation 1 domain containing 1
• NCBI Official Symbol: DCUN1D1
• NCBI Official Synonym Symbols: RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
• NCBI Protein Information: DCN1-like protein 1
• UniProt Protein Name: DCN1-like protein 1
• Protein Family: DCN1-like protein
• UniProt Gene Name: DCUN1D1

Uniprot Description

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression ().