Rat doublecortin-like kinase 2 ELISA Kit | DCLK2 elisa kit
Rat Serine/threonine-protein kinase DCLK2, DCLK2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that this gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Uniprot Description
DCAMKL2: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CAMK; CAMK group; DCAMKL family
Cellular Component: cytoskeleton; cytoplasm
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: protein amino acid phosphorylation
Research Articles on DCLK2
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Product Notes
The Rat DCLK2 dclk2 (Catalog #AAA9335058) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335058 ELISA Kit recognizes Rat DCLK2. It is sometimes possible for the material contained within the vial of "doublecortin-like kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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