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DAO / D-Amino-Acid Oxidase Recombinant Protein | DAO recombinant protein

Human DAO / D-Amino-Acid Oxidase Recombinant Protein

Gene Names
DAO; DAAO; OXDA; DAMOX
Applications
ELISA, Western Blot
Purity
>95% by SDS-PAGE
Synonyms
DAO / D-Amino-Acid Oxidase; Human DAO / D-Amino-Acid Oxidase Recombinant Protein; D-amino-acid oxidase; DAAO; DAMOX; DAO recombinant protein
Ordering
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
Concentration
Reconstitution Dependent (varies by lot)
Sequence Length
347
Applicable Applications for DAO recombinant protein
ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
Species
Human
Tag
His
Subunit
Homodimer.
Entry Function
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Preparation and Storage
Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
D-amino-acid oxidase
NCBI Official Synonym Full Names
D-amino acid oxidase
NCBI Official Symbol
DAO
NCBI Official Synonym Symbols
DAAO; OXDA; DAMOX
NCBI Protein Information
D-amino-acid oxidase
UniProt Protein Name
D-amino-acid oxidase
Protein Family
UniProt Gene Name
DAO
UniProt Synonym Gene Names
DAMOX; DAAO; DAMOX; DAO
UniProt Entry Name
OXDA_HUMAN

NCBI Description

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Uniprot Description

DAO: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. Belongs to the DAMOX/DASOX family.

Protein type: Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - arginine and proline; Other Amino Acids Metabolism - D-Arginine and D-ornithine; EC 1.4.3.3

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: peroxisomal membrane; peroxisomal matrix; mitochondrial outer membrane; peroxisome; cytosol

Molecular Function: protein dimerization activity; protein binding; cofactor binding; D-amino-acid oxidase activity; receptor binding

Biological Process: proline catabolic process; glyoxylate metabolic process; dopamine biosynthetic process; leucine metabolic process

Disease: Schizophrenia

Research Articles on DAO

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Product Notes

The DAO dao (Catalog #AAA2902490) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DAO / D-Amino-Acid Oxidase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the DAO dao for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DAO / D-Amino-Acid Oxidase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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