Rat diacylglycerol lipase, alpha ELISA Kit | DAGLA elisa kit
Rat Sn1-specific diacylglycerol lipase alpha, DAGLA ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NSDDR: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Defects in DAGLA may be a cause of spinocerebellar ataxia type 20 (SCA20). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult- onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA. Belongs to the AB hydrolase superfamily. Lipase family.
Protein type: EC 3.1.1.-; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase
Cellular Component: integral to membrane; plasma membrane
Molecular Function: metal ion binding; lipase activity
Biological Process: neurogenesis; neuroblast proliferation; arachidonic acid metabolic process; diacylglycerol catabolic process; lipid metabolic process; neurotransmitter biosynthetic process
Research Articles on DAGLA
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Product Notes
The Rat DAGLA dagla (Catalog #AAA9336736) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336736 ELISA Kit recognizes Rat DAGLA. It is sometimes possible for the material contained within the vial of "diacylglycerol lipase, alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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