Rat DAB2 interacting protein ELISA Kit | DAB2IP elisa kit
Rat Disabled homolog 2-interacting protein, DAB2IP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
GTPase-activating protein; binds the N-terminal domain of DOC-2/DAB2 [RGD, Feb 2006]
Uniprot Description
DAB2IP: Functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK- NF-kappa-B signaling. May act as a tumor suppressor gene. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Ras; Tumor suppressor
Cellular Component: cell soma; axon; endocytic vesicle; dendrite; cytoplasm; plasma membrane; intracellular
Molecular Function: identical protein binding; protein homodimerization activity; protein phosphatase 2A binding; mitogen-activated protein kinase kinase binding; death receptor binding; protein N-terminus binding; mitogen-activated protein kinase kinase kinase binding; protein kinase binding; GTPase activator activity; protein binding; vascular endothelial growth factor receptor 2 binding; protein complex binding; phosphoinositide 3-kinase binding; kinase binding; SH3 domain binding; phosphatidylinositol 3-phosphate binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of JNK activity; negative regulation of MAP kinase activity; regulation of protein heterodimerization activity; apoptosis; positive regulation of apoptosis; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; activation of JNK activity; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase activity; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; negative regulation of Ras protein signal transduction; regulation of protein complex assembly; angiogenesis; regulation of I-kappaB kinase/NF-kappaB cascade; layer formation in the cerebral cortex; negative regulation of epithelial cell proliferation; negative regulation of vascular endothelial growth factor receptor signaling pathway; lumen formation; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to unfolded protein; negative regulation of angiogenesis; induction of apoptosis via death domain receptors; negative regulation of fibroblast proliferation; cellular protein catabolic process; inhibition of NF-kappaB transcription factor; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of protein catabolic process; activation of MAPKKK activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; I-kappaB phosphorylation; negative regulation of transcription, DNA-dependent; cell locomotion involved in cerebral cortex radial glia guided migration; positive regulation of epithelial cell proliferation; neurite morphogenesis; negative regulation of phosphoinositide 3-kinase cascade
Research Articles on DAB2IP
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Product Notes
The Rat DAB2IP dab2ip (Catalog #AAA9333734) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333734 ELISA Kit recognizes Rat DAB2IP. It is sometimes possible for the material contained within the vial of "DAB2 interacting protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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