Caspase-6 Blocking Peptide | D162 blocking peptide

Caspase-6 p18 (D162) Peptide

Cat. Num. AAA3008369

• Gene Names: Casp6; Mch2; CASP-6
• Applications: Blocking
• Purity: Synthetic peptide Caspase-6 p18 (D162). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Caspase-6; Caspase-6 p18 (D162) Peptide; MCH2; CASP6; Caspase 6; Caspase6; D162 blocking peptide

• Specificity: This peptide can be used with studies using MBS3008368 Caspase-6 p18 (D162) pAb.
• Purity/Purification: Synthetic peptide Caspase-6 p18 (D162). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 276

• Applicable Applications for D162 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for D162 blocking peptide

Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A. The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death.

NCBI and Uniprot Product Information

• NCBI GI #: 157951736
• NCBI GeneID: 12368
• NCBI Accession #: NP_033941.3
• NCBI GenBank Nucleotide #: NP_033941.3
• UniProt Accession #: O08738
• NCBI Official Full Name: caspase-6
• NCBI Official Synonym Full Names: caspase 6
• NCBI Official Symbol: Casp6
• NCBI Official Synonym Symbols: Mch2; CASP-6
• NCBI Protein Information: caspase-6
• UniProt Protein Name: Caspase-6
• Protein Family: Caspase
• UniProt Gene Name: Casp6
• UniProt Synonym Gene Names: CASP-6
• UniProt Entry Name: CASP6_MOUSE

NCBI Description

This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]

Uniprot Description

CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Protease; EC 3.4.22.59

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: peptidase activity; identical protein binding; protein binding; hydrolase activity; endopeptidase activity; cysteine-type peptidase activity

Biological Process: regulation of apoptosis; response to hydrogen peroxide; positive regulation of apoptosis; positive regulation of retinal cell programmed cell death; positive regulation of neuron apoptosis; response to cytokine stimulus; acute inflammatory response to non-antigenic stimulus; response to glucose stimulus; proteolysis; response to iron ion