Cytochrome P450 2C8/9/18/19 Blocking Peptide | CYP2C18 blocking peptide

Cytochrome P450 2C8/9/18/19 Blocking Peptide

Cat. Num. AAA9623749

• Gene Names: CYP2C18; CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Cytochrome P450 2C8/9/18/19; Cytochrome P450 2C8/9/18/19 Blocking Peptide; (S) mephenytoin hydroxylase associated cytochrome P450; CPCI; CYP2C 18; CYP2C; CYP2C17; CYPIIC18; Cytochrome P450 2C18; Cytochrome P450 6B/29C; Cytochrome P450 family 2 subfamily C polypeptide 18; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 17; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 18; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 6B/29C; P450IIC17; Unspecific monooxygenase; CP2C8_HUMAN; CPC8; CYP2C8; CYPIIC8; Cytochrome P450 2C8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; S-mephenytoin 4-hydroxylase; Xenobiotic monooxygenase; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CP2C9_HUMAN; CPC9; CYP2C10; CYP2C9; CYPIIC9; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; Cytochrome P450; family 2; subfamily C; polypeptide 9; Cytochrome p4502C9; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; OTTHUMP00000020135; P450 MP; P450 PB 1; P450 PB1; P450IIC9; P450MP; xenobiotic monooxygenase; CYP2C19; CYPIIC17; CYPIIC19; Cytochrome P450 2C19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase; CYP2C18 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for CYP2C18 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CYP2C18 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 13699816
• NCBI GeneID: 1562
• NCBI Accession #: NP_000763.1
• NCBI GenBank Nucleotide #: NM_000772.2
• UniProt Accession #: P33260; Q16703; Q16751; Q4VAT5; Q6GRG1; B2R8K2
• Molecular Weight: 48,805 Da
• NCBI Official Full Name: cytochrome P450 2C18 isoform 1
• NCBI Official Synonym Full Names: cytochrome P450 family 2 subfamily C member 18
• NCBI Official Symbol: CYP2C18
• NCBI Official Synonym Symbols: CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
• NCBI Protein Information: cytochrome P450 2C18
• UniProt Protein Name: Cytochrome P450 2C18
• Protein Family: Cytochrome
• UniProt Gene Name: CYP2C18

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.