Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) Recombinant Protein | CYLD recombinant protein

Recombinant Bovine Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD); Recombinant Bovine Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD); partial; CYLD recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 953

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CYLD recombinant protein

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI and Uniprot Product Information

• NCBI GI #: 114051812
• NCBI GeneID: 536421
• NCBI Accession #: NP_001039882.1
• NCBI GenBank Nucleotide #: NM_001046417.1
• UniProt Accession #: Q1RMU2
• Molecular Weight: 106,805 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase CYLD
• NCBI Official Synonym Full Names: CYLD lysine 63 deubiquitinase
• NCBI Official Symbol: CYLD
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase CYLD
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase CYLD
• Protein Family: Ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: CYLD
• UniProt Synonym Gene Names: CYLD1

Uniprot Description

Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (). Negative regulator of Wnt signaling (). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (). Required for normal cell cycle progress and normal cytokinesis (). Inhibits nuclear translocation of NF-kappa-B (). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation ().