Growth Regulated Oncogene Gamma (GROg) Recombinant Protein | GROg recombinant protein

Recombinant Growth Regulated Oncogene Gamma (GROg)

Cat. Num. AAA2010735

• Gene Names: CXCL3; GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Growth Regulated Oncogene Gamma (GROg); Recombinant Growth Regulated Oncogene Gamma (GROg); GROg recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGS-ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN
• Sequence Length: 107

• Applicable Applications for GROg recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Ala35~Asn107 (Accession # P19876) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

NCBI and Uniprot Product Information

• NCBI GI #: 54144650
• NCBI GeneID: 2921
• NCBI Accession #: NP_002081.2
• NCBI GenBank Nucleotide #: NM_002090.2
• UniProt Accession #: P19876; Q4W5H9
• Molecular Weight: 9.1kDa
• NCBI Official Full Name: C-X-C motif chemokine 3
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 3
• NCBI Official Symbol: CXCL3
• NCBI Official Synonym Symbols: GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
• NCBI Protein Information: C-X-C motif chemokine 3; GRO-gamma; MIP2-beta; MGSA gamma; GRO3 oncogene; GRO-gamma(1-73); growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma
• UniProt Protein Name: C-X-C motif chemokine 3
• UniProt Gene Name: CXCL3
• UniProt Synonym Gene Names: GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta
• UniProt Entry Name: CXCL3_HUMAN

NCBI Description

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

Uniprot Description

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; inflammatory response; regulation of cell proliferation