CXCL11 recombinant protein

CXCL11 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122566

• Gene Names: Cxcl11; Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CXCL11; CXCL11 Protein; Mouse; Recombinant (His Tag); Mouse I-TAC/CXCL11 protein (His Tag); b-R1 Protein; betaR1 Protein; Cxc11 Protein; H174 Protein; I-tac Protein; Ip9 Protein; Itac Protein; Scyb11 Protein; Scyb9b Protein; chemokine (C-X-C motif) ligand 11; CXCL11 recombinant protein

• Host: Yeast
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Phe22-Met100

• Species: Mouse
• Predicted N Terminal: Phe 22
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse Cxcl11 (NP_062367.1)(Phe22-Met100) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CXCL11 recombinant protein

Background: I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

References

Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903. Rani MR, et al. (2002) Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. J Biol Chem. 277(41): 38456-61. Salmaggi A, et al. (2003) Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J Interferon Cytokine Res. 22(6):631-40.

NCBI and Uniprot Product Information

• NCBI GI #: 9507071
• NCBI GeneID: 56066
• NCBI Accession #: NP_062367.1
• NCBI GenBank Nucleotide #: NM_019494.1
• UniProt Accession #: Q9JHH5
• Molecular Weight: 11,266 Da
• NCBI Official Full Name: C-X-C motif chemokine 11
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 11
• NCBI Official Symbol: Cxcl11
• NCBI Official Synonym Symbols: Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1
• NCBI Protein Information: C-X-C motif chemokine 11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small-inducible cytokine B11
• UniProt Protein Name: C-X-C motif chemokine 11
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: Cxcl11
• UniProt Synonym Gene Names: Scyb11; I-TAC
• UniProt Entry Name: CXL11_MOUSE

Uniprot Description

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation