Goat Cortactin ELISA Kit | CTTN elisa kit

Goat Cortactin (CTTN) ELISA Kit

Cat. Num. AAA2604683

• Gene Names: CTTN; EMS1
• Reactivity: Goat
• Synonyms: Cortactin; Goat Cortactin (CTTN) ELISA Kit; CTTN elisa kit

• Reactivity: Goat
• Sequence Length: 634

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 296080746
• NCBI GeneID: 2017
• NCBI Accession #: NP_001171669.1
• NCBI GenBank Nucleotide #: NM_001184740.1
• Molecular Weight: 57,467 Da
• NCBI Official Full Name: src substrate cortactin isoform c
• NCBI Official Synonym Full Names: cortactin
• NCBI Official Symbol: CTTN
• NCBI Official Synonym Symbols: EMS1
• NCBI Protein Information: src substrate cortactin
• UniProt Protein Name: Src substrate cortactin
• Protein Family: Cortactin-binding protein
• UniProt Gene Name: CTTN
• UniProt Synonym Gene Names: EMS1
• UniProt Entry Name: SRC8_HUMAN

NCBI Description

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Uniprot Description

Cortactin: a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches. The central region of the protein contains six repeats of 37 amino acids that are important in F-actin binding and cross-linking. The carboxy-terminus contains a proline-rich region and an SH3 domain that can interact with numerous scaffolding proteins, such as CortBP1 and Shank3. Cortactin may play a role in the organization of transmembrane receptors at postsynaptic densities (PSD) and tight junctions by linking scaffolding proteins to the actin network. It is degraded in a caspase-dependent manner during apoptosis. It is overexpressed in numerous cancers with poor patient prognosis. It may contribute to tumor cell invasion and metastasis. Two splice variant isoforms have been identified.

Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: actin filament; cell cortex; coated pit; cortical cytoskeleton; cytoplasm; cytoskeleton; dendritic spine; focal adhesion; Golgi apparatus; growth cone; intracellular membrane-bound organelle; lamellipodium; plasma membrane; podosome; ruffle; voltage-gated potassium channel complex

Molecular Function: profilin binding; protein binding

Biological Process: actin cytoskeleton reorganization; actin filament polymerization; cell motility involved in cell locomotion; focal adhesion formation; intracellular protein transport; neurite morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of axon extension; small GTPase mediated signal transduction; substrate-bound cell migration, cell extension