CTSV recombinant protein

Recombinant Human CTSV Protein

Cat. Num. AAA8248889

• Gene Names: CTSV; CTSU; CATL2; CTSL2
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Synonyms: CTSV; Recombinant Human CTSV Protein; CATL2; CTSL2; CTSU; Cathepsin L2; Cathepsin U; Cathepsin V; CTSV recombinant protein

• Host: Human cells
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 muM filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
• Sequence: VPKFDQNLDT KWYQWKATHR RLYGANEEGW RRAVWEKNMK MIELHNGEYS QGKHGFTMAM NAFGDMTNEE FRQMMGCFRN QKFRKGKVFR EPLFLDLPKS VDWRKKGYVT PVKNQKQCGS CWAFSATGAL EGQMFRKTGK LVSLSEQNLV DCSRPQGNQG CNGGFMARAF QYVKENGGLD SEESYPYVAV DEICKYRPEN SVANDTGFTV VAPGKEKALM KAVATVGPIS VAMDAGHSSF QFYKSGIYFE PDCSSKNLDH GVLVVGYGFE GANSNNSKYW LVKNSWGPEW GSNGYVKIAK DKNNHCGIAT AASYPNVVDH HHHHH
• Sequence Length: 334

• Applicable Applications for CTSV recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for CTSV recombinant protein

Recombinant Human CTSV Protein is produced by our Mammalian expression system and the target gene encoding Val18-Val334 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 320118898
• NCBI GeneID: 1515
• NCBI Accession #: NP_001188504.1
• NCBI GenBank Nucleotide #: NM_001201575.1
• UniProt Accession #: O60911; O60233; Q2TB86; Q5T1U0
• Molecular Weight: 37,329 Da
• NCBI Official Full Name: cathepsin L2 preproprotein
• NCBI Official Synonym Full Names: cathepsin V
• NCBI Official Symbol: CTSV
• NCBI Official Synonym Symbols: CTSU; CATL2; CTSL2
• NCBI Protein Information: cathepsin L2
• UniProt Protein Name: Cathepsin L2
• UniProt Gene Name: CTSV
• UniProt Synonym Gene Names: CATL2; CTSL2; CTSU
• UniProt Entry Name: CATL2_HUMAN

NCBI Description

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

Uniprot Description

CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.15; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular region; extracellular space; lysosomal lumen; lysosome

Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; extracellular matrix disassembly; proteolysis involved in cellular protein catabolic process