Cathepsin K Recombinant Protein | CATK recombinant protein
Recombinant mouse Cathepsin K
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]
Uniprot Description
CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.
Protein type: EC 3.4.22.38; Protease
Chromosomal Location of Human Ortholog: 3 F2.1|3 40.74 cM
Cellular Component: cytoplasm; extracellular space; intracellular membrane-bound organelle; lysosome; nucleoplasm
Molecular Function: collagen binding; cysteine-type endopeptidase activity; fibronectin binding; proteoglycan binding
Biological Process: bone resorption; collagen catabolic process; proteolysis involved in cellular protein catabolic process
Research Articles on CATK
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Product Notes
The CATK ctsk (Catalog #AAA9420154) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Full Length, 115-329aa. The Recombinant mouse Cathepsin K reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: PDSIDYRKKG YVTPVKNQGQ CGSCWAFSSA GALEGQLKKK TGKLLALSPQ NLVDCVTENY GCGGGYMTTA FQYVQQNGGI DSEDAYPYVG QDESCMYNAT AKAAKCRGYR EIPVGNEKAL KRAVARVGPI SVSIDASLAS FQFYSRGVYY DENCDRDNVN HAVLVVGYGT QKGSKHWIIK NSWGESWGNK GYALLARNKN NACGITNMAS FPKM. It is sometimes possible for the material contained within the vial of "Cathepsin K, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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