Rat Dipeptidyl peptidase 1 ELISA Kit | Ctsc elisa kit

Rat Dipeptidyl peptidase 1 ELISA Kit

Cat. Num. AAA2882143

• Gene Names: Ctsc; CATC; DPPI; DPP-I
• Reactivity: Rat
• Synonyms: Dipeptidyl peptidase 1; Rat Dipeptidyl peptidase 1 ELISA Kit; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase; Ctsc; 3.4.14.1; Ctsc elisa kit

• Reactivity: Rat
• Sequence Length: 462

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.168 ng/mL
• Intra-Assay CV: <=4.7%
• Inter-Assay CV: <=8.6%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 8393218
• NCBI GeneID: 25423
• NCBI Accession #: NP_058793.1
• NCBI GenBank Nucleotide #: NM_017097.1
• UniProt Accession #: P80067; P80068
• Molecular Weight: 52,235 Da
• NCBI Official Full Name: dipeptidyl peptidase 1
• NCBI Official Synonym Full Names: cathepsin C
• NCBI Official Symbol: Ctsc
• NCBI Official Synonym Symbols: CATC; DPPI; DPP-I
• NCBI Protein Information: dipeptidyl peptidase 1
• UniProt Protein Name: Dipeptidyl peptidase 1
• Protein Family: Dipeptidyl peptidase
• UniProt Gene Name: Ctsc
• UniProt Synonym Gene Names: DPP-I; DPPI
• UniProt Entry Name: CATC_RAT

NCBI Description

acts as a cysteine dipeptidyl aminopeptidase; may play a role in immune and inflammatory response [RGD, Feb 2006]

Uniprot Description

CTSC: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Defects in CTSC are a cause of Papillon-Lefevre syndrome (PLS); also known as keratosis palmoplantaris with periodontopathia. PLS is an autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Defects in CTSC are a cause of Haim-Munk syndrome (HMS); also known as keratosis palmoplantaris with periodontopathia and onychogryposis or Cochin Jewish disorder. HMS is an autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Defects in CTSC are a cause of aggressive periodontititis type 1 (AP1); also known as juvenile periodontitis (JPD) and prepubertal periodontitis (PPP). AP1 is characterized by severe and protracted gingival infections, leading to tooth loss. AP1 inheritance is autosomal dominant. Belongs to the peptidase C1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Protease; EC 3.4.14.1

Cellular Component: endoplasmic reticulum; extracellular space; Golgi apparatus; lysosome; membrane

Molecular Function: apoptotic protease activator activity; chaperone binding; chloride ion binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; phosphatase binding; protein self-association; serine-type endopeptidase activity

Biological Process: aging; apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; response to organic substance; T cell mediated cytotoxicity