Cathepsin A/CTSA Recombinant Protein | CTSA recombinant protein

Recombinant Human Cathepsin A/CTSA Protein (C-6His)

Cat. Num. AAA2552445

• Gene Names: CTSA; GSL; GLB2; NGBE; PPCA; PPGB
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Cathepsin A/CTSA; Recombinant Human Cathepsin A/CTSA Protein (C-6His); Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; CTSA recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Ala29-Tyr480
• Sequence Length: 498

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for CTSA recombinant protein

Cathepsin A is active in cellular compartments called lysosomes. These compartments contain enzymes that digest and recycle materials when they are no longer needed. Cathepsin A interacts with the enzymes beta-galactosidase and neuraminidase 1, which play a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) or fats (glycolipids). Cathepsin A forms a complex with these two enzymes and directs their transport within the cell to the lysosomes. Within lysosomes, cathepsin A activates the enzymes and prevents their breakdown.

NCBI and Uniprot Product Information

• NCBI GI #: 119395729
• NCBI GeneID: 5476
• NCBI Accession #: NP_000299.2
• NCBI GenBank Nucleotide #: NM_000308.3
• UniProt Accession #: P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68; B2R798
• Molecular Weight: Molecular Mass: 52.2 kDa; Actual Protein Molecular Mass: 58-60 kDa
• NCBI Official Full Name: lysosomal protective protein isoform a
• NCBI Official Synonym Full Names: cathepsin A
• NCBI Official Symbol: CTSA
• NCBI Official Synonym Symbols: GSL; GLB2; NGBE; PPCA; PPGB
• NCBI Protein Information: lysosomal protective protein
• UniProt Protein Name: Lysosomal protective protein
• Protein Family: Lysosomal protective protein
• UniProt Gene Name: CTSA
• UniProt Synonym Gene Names: PPGB; PPCA

NCBI Description

This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]

Uniprot Description

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.