SDS-Page
(Recombinant Human GM-CSF R alpha/CSF2RA Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
GM-CSF R alpha/CSF2RA Recombinant Protein | CSF2RA recombinant protein
Recombinant Human GM-CSF R alpha/CSF2RA Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human GM-CSF R alpha/CSF2RA Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
SDS-Page
(Recombinant Human GM-CSF R alpha/CSF2RA Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
Background: Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit alpha (CSF2RA) is a single-pass type Imembrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA geneis found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms beingmembrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophagecolony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, andfunctional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactantmetabolism dysfunction type 4 (SMDP4).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Uniprot Description
CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3
Cellular Component: integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; receptor activity
Biological Process: response to ethanol; cytokine and chemokine mediated signaling pathway
Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4
Research Articles on CSF2RA
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Product Notes
The CSF2RA csf2ra (Catalog #AAA9139995) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: EKSDLRTVAP ASSLNVRFDS RTMNLSWDCQ ENTTFSKCFL TDKKNRVVEP RLSNNECSCT FREICLHEGV TFEVHVNTSQ RGFQQKLLYP NSGREGTAAQ NFSCFIYNAD LMNCTWARGP TAPRDVQYFL YIRNSKRRRE IRCPYYIQDS GTHVGCHLDN LSGLTSRNYF LVNGTSREIG IQFFDSLLDT KKIERFNPPS NVTVRCNTTH CLVRWKQPRT YQKLSYLDFQ YQLDVHRKNT QPGTENLLIN VSGDL. It is sometimes possible for the material contained within the vial of "GM-CSF R alpha/CSF2RA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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