Human Thiomorpholine-carboxylate dehydrogenase ELISA Kit | CRYM elisa kit
Human Thiomorpholine-carboxylate dehydrogenase ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]
Uniprot Description
CRYM: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Belongs to the ornithine cyclodeaminase family.
Protein type: EC 1.5.1.25; Lyase
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytoplasm; cytosol; peroxisomal matrix
Molecular Function: NADP binding; oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; protein binding; protein homodimerization activity; thiomorpholine-carboxylate dehydrogenase activity; transcription corepressor activity
Biological Process: lysine catabolic process; negative regulation of transcription from RNA polymerase II promoter; sensory perception of sound; thyroid hormone metabolic process
Disease: Deafness, Autosomal Dominant 40
Research Articles on CRYM
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Product Notes
The Human CRYM crym (Catalog #AAA9426727) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426727 ELISA Kit recognizes Human CRYM. It is sometimes possible for the material contained within the vial of "Thiomorpholine-carboxylate dehydrogenase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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