Alpha-crystallin A chain (CRYAA) Recombinant Protein | CRYAA recombinant protein
Recombinant Columba livia Alpha-crystallin A chain (CRYAA)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Alpha-crystallin A chain (CRYAA); Recombinant Columba livia Alpha-crystallin A chain (CRYAA); Alpha-crystallin A chain; CRYAA recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-149aa; full length protein
Sequence
RALGPLIPSR LFDQFFGEGL LEYDLLPWFS STISPYYRQS LFRSVLESGI SEVRSDREKFTIMLDVKHFS PEDLSVKIID DFVEIHGKHS ERQDDHGYIS REFHRRYRLP ANVDQAAITCSLSNDGMLTF SGPKVPANMD ASHGERPIP
Sequence Length
149
Species
Columba livia (Domestic pigeon)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for CRYAA recombinant protein
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
17,059 Da
NCBI Official Full Name
Alpha-crystallin A chain, partial
NCBI Official Symbol
CRYAA
NCBI Protein Information
crystallin, alpha A; alpha A-crystallin; alpha-A-crystallin; Alpha-crystallin A chain
UniProt Protein Name
Alpha-crystallin A chain
Protein Family
UniProt Gene Name
CRYAA
UniProt Entry Name
CRYAA_COLLI
Uniprot Description
May contribute to the transparency and refractive index of the lens.
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Product Notes
The CRYAA cryaa (Catalog #AAA1156963) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-149aa; full length protein. The amino acid sequence is listed below: RALGPLIPSR LFDQFFGEGL LEYDLLPWFS STISPYYRQS LFRSVLESGI SEVRSDREKF TIMLDVKHFS PEDLSVKIID DFVEIHGKHS ERQDDHGYIS REFHRRYRLP ANVDQAAITC SLSNDGMLTF SGPKVPANMD ASHGERPIP. It is sometimes possible for the material contained within the vial of "Alpha-crystallin A chain (CRYAA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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