CD355 recombinant protein

Recombinant Human CD355 protein, C-His Tag

Cat. Num. AAA1560652

• Gene Names: CRTAM; CD355
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD355; Recombinant Human CD355 protein; C-His Tag; CD355 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human CRTAM (Met1-Ser286) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD355 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 755571554
• NCBI GeneID: 56253
• NCBI Accession #: NP_001291711.1
• NCBI GenBank Nucleotide #: NM_001304782.1
• UniProt Accession #: O95727; Q59EI1; Q6IRX2
• Molecular Weight: 22,256 Da
• NCBI Official Full Name: cytotoxic and regulatory T-cell molecule Isoform 2
• NCBI Official Synonym Full Names: cytotoxic and regulatory T-cell molecule
• NCBI Official Symbol: CRTAM
• NCBI Official Synonym Symbols: CD355
• NCBI Protein Information: cytotoxic and regulatory T-cell molecule
• UniProt Protein Name: Cytotoxic and regulatory T-cell molecule
• UniProt Gene Name: CRTAM
• UniProt Entry Name: CRTAM_HUMAN

Uniprot Description

CRTAM: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: activated T cell proliferation; cell recognition; detection of stimulus; detection of tumor cell; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of cytokine secretion; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; T cell mediated cytotoxicity