C-Reactive Protein, Western Blot Control Recombinant Protein | CRP recombinant protein

C-Reactive Protein, Recombinant, Human, Western Blot Control (CRP, PTX1)

Cat. Num. AAA637730

• Gene Names: CRP; PTX1
• Applications: Western Blot
• Purity: Purified; Purified (SDS-PAGE)
• Synonyms: C-Reactive Protein; Western Blot Control; Recombinant; Human; Western Blot Control (CRP; PTX1); CRP recombinant protein

• Purity/Purification: Purified; Purified (SDS-PAGE)
• Form/Format: Supplied as a liquid in 25mM Tris-HCl, pH6.8, 50mM DTT, 1% SDS, 0.1% Bromophenol Blue, 2.5% glycerol.

• Applicable Applications for CRP recombinant protein: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot as a control.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for CRP recombinant protein

Human C reactive protein (CRP) is a member of the pentraxin family of serum proteins and is composed of five identical non- covalently linked subunits. CRP is one of the major plasma proteins that increase in concentration during the acute phase response to tissue injury or inflammation. Increased serum levels of CRP have been associated with myocardial infarction, atherosclerosis and end-stage kidney disease.

Product Categories/Family for CRP recombinant protein

Molecular Biology; MB-Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 55770842
• NCBI GeneID: 1401
• NCBI Accession #: NP_000558.2
• NCBI GenBank Nucleotide #: NM_000567.2
• UniProt Accession #: P02741; Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
• Molecular Weight: 25,039 Da
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1
• NCBI Protein Information: C-reactive protein; pentraxin 1
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Description

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; virion binding; low-density lipoprotein binding; cholesterol binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; wound healing; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging